Letrozole is is a nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity..
Letrozole is a nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity.
a third-generation aromatase inhibitor, is As Letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells..
As a third-generation aromatase inhibitor, Letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells.
Aromatase, is a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis..
Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis.
the conversion of androgens is Estrogens are produced by through the activity of the aromatase enzyme..
Estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme.
Letrozole is blocks production of estrogens in this way by competitive, reversible binding to the heme of its cytochrome P450 unit..
Letrozole blocks production of estrogens in this way by competitive, reversible binding to the heme of its cytochrome P450 unit.
The action is is specific, and letrozole does not reduce production of mineralo- or corticosteroids..
The action is specific, and letrozole does not reduce production of mineralo- or corticosteroids.
contrast, is In the antiestrogenic action of tamoxifen, the major medical therapy prior to the arrival of aromatase inhibitors, is due to its interfering with the estrogen receptor, rather than inhibiting estrogen production..
In contrast, the antiestrogenic action of tamoxifen, the major medical therapy prior to the arrival of aromatase inhibitors, is due to its interfering with the estrogen receptor, rather than inhibiting estrogen production.
Letrozole is is approved by the United States Food and Drug Administration (FDA) for the treatment of local or metastatic breast cancer that is hormone receptor positive or has an unknown receptor status in postmenopausal women..
Letrozole is approved by the United States Food and Drug Administration (FDA) for the treatment of local or metastatic breast cancer that is hormone receptor positive or has an unknown receptor status in postmenopausal women.
effects is Side include signs and symptoms of hypoestrogenism..
Side effects include signs and symptoms of hypoestrogenism.
concern is There is that long term use may lead to osteoporosis, which is why prescriptions of Letrozole are often accompanied by prescriptions of osteoporosis-fighting medication such as Fosamax..
There is concern that long term use may lead to osteoporosis, which is why prescriptions of Letrozole are often accompanied by prescriptions of osteoporosis-fighting medication such as Fosamax.
Letrozole is has shown to reduce estrogen levels by 98 percent while raising testosterone levels..
Letrozole has shown to reduce estrogen levels by 98 percent while raising testosterone levels.
The anti-estrogen action of letrozole is is preferred by athletes and bodybuilders for use during a steroid cycle to reduce bloating due to excess water retention and prevent the formation of gynecomastia related breast tissue that is a side effect of some anabolic steroids..
The anti-estrogen action of letrozole is preferred by athletes and bodybuilders for use during a steroid cycle to reduce bloating due to excess water retention and prevent the formation of gynecomastia related breast tissue that is a side effect of some anabolic steroids.
Usage above 2.5 mg/day is is known to potentially temporarily kill sex drive..
Usage above 2.5 mg/day is known to potentially temporarily kill sex drive.
Above 5mg/day is for extended periods may cause kidney problems..
Above 5mg/day for extended periods may cause kidney problems.
Letrozole is has also been shown to delay the fusing of the growth plates in adolescents..
Letrozole has also been shown to delay the fusing of the growth plates in adolescents.
the effectiveness of growth hormone, is This may boost and thus Letrozole is used to treat adolescents and children with short stature..
This may boost the effectiveness of growth hormone, and thus Letrozole is used to treat adolescents and children with short stature.
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